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黃連堿
分析標(biāo)準(zhǔn)品,HPLC≥98%
Coptisine
CAS號：3486-66-6
分子式：C19H14NO4+
分子量：320.32
MDL：MFCD03792689
貨號 | 規(guī)格/參數(shù)/品牌 | 價格 | 貨期 |
YJ-B20560-10mg | 分析標(biāo)準(zhǔn)品,HPLC≥98% | ￥550.00 | 現(xiàn)貨 |
YJ-B20560-20mg | 分析標(biāo)準(zhǔn)品,HPLC≥98% | ￥850.00 | 現(xiàn)貨 |
產(chǎn)品介紹
熔點(diǎn)：212-217 ℃
外觀：淺黃色針狀結(jié)晶 (乙醇)
溶解性：極略微溶于水,微溶于乙醇,溶于堿
儲存條件：2-8℃
注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。
參考文獻(xiàn)(60篇)
60. [IF=6.7] Mingzhu Qi et al."Qingxin Jieyu Granule alleviates myocardial infarction through inhibiting neutrophil extracellular traps via activating ANXA1/FPR2 axis."PHYTOMEDICINE.2024 Dec;135:156147
59. [IF=4.1] Yufeng Huang et al."Study on the correlation between alkaloids and tastes of Coptis Rhizome from four species based on UHPLC-QQQ-MS/MS combined with electronic tongue technique."Frontiers in Plant Science.2024 Nov;15:
58. [IF=3.1] Qian Chunmei et al."Coptisine inhibits esophageal carcinoma growth by modulating pyroptosis via inhibition of HGF/c-Met signaling."NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY.2025 Jan;:1-15
57. [IF=1.8] Panpan Wang et al."In vivo and in vitro chemical composition and biological activity of traditional vs. dispensing granule decoctions of Coptidis Rhizoma: A comparative study."BIOMEDICAL CHROMATOGRAPHY.2024 Jul;:e5960
56. [IF=4.1] Huaixin Liu et al."A magnetic beads-based ligand fishing method for rapid discovery of monoterpene indoles as monoamine oxidase A inhibitors from Hunteria zeylanica."JOURNAL OF CHROMATOGRAPHY A".2024 May;1722:464896
55. [IF=4.9] Xueyu Pu et al."Lipids Extracted from Mycobacterial Membrane and Enveloped PLGA Nanoparticles for Encapsulating Antibacterial Drugs Elicit Synergistic Antimicrobial Response against Mycobacteria."MOLECULAR PHARMACEUTICS".2024;21(5):2238–2249
54. [IF=5.4] Sihao Zhang et al."Chang-Kang-Fang alleviates diarrhea predominant irritable bowel syndrome (IBS-D) through inhibiting TLR4/NF-κB/NLRP3 pathway."JOURNAL OF ETHNOPHARMACOLOGY".2024 Apr;:118236
53. [IF=5.4] Wenjuan Ma et al."Uncovering the key pharmacodynamic material basis and possible molecular mechanism of Xiaoke formulation improve insulin resistant through a comprehensive investigation."JOURNAL OF ETHNOPHARMACOLOGY.2024 Apr;323:117752
52. [IF=7.9] Shan Zhang et al."Enhancing β-Cell Function and Identity in type 2 diabetes: The Protective Role of Coptis deltoidea C. Y. Cheng et Hsiao via Glucose Metabolism Modulation and AMPK Signaling Activation."PHYTOMEDICINE.2024 Jan;:155396
51. [IF=2.9] Qi Ying et al."Sanhuang Xiexin Decoction Ameliorates TNBC By Modulating JAK2-STAT3 and Lipid Metabolism."Chinese Journal of Integrative Medicine.2023 Nov;:1-10
50. [IF=7.9] Min Zhao et al."N6-methyladenosine modification of TSC1 mRNA contributes to macrophage polarization regulated by Coptisine in DSS-induced ulcerative colitis."PHYTOMEDICINE.2023 Oct;:155153
49. [IF=4.6] Fengge YANG et al."Deciphering chemical and metabolite profiling of Chang-Kang-Fang by UPLC-Q-TOF-MS/MS and its potential active components identification."Chinese Journal of Natural Medicines.2023 Jun;21:459
48. [IF=7.9] Jiangna Yan et al."Blocking LTB4 Signaling-mediated TAMs Recruitment by Rhizoma Coptidis Sensitizes Lung Cancer to Immunotherapy."PHYTOMEDICINE.2023 Jul;:154968
47. [IF=6.5] Wei Liu et al."Genome-wide analysis of bHLH gene family in Coptis chinensis provides insights into the regulatory role in benzylisoquinoline alkaloid biosynthesis."PLANT PHYSIOLOGY AND BIOCHEMISTRY.2023 Aug;201:107846
46. [IF=3.571] Ning Zhou et al."Exploring the efficacy mechanism and material basis of three processed Coptidis Rhizoma via metabolomics strategy."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2023 Aug;232:115450
45. [IF=6.656] Ning Zhou et al."Characterizing the specific mechanism of series processed Coptidis Rhizoma by multi-organ metabolomics combined with network pharmacology and molecular docking."PHYTOMEDICINE.2023 Jun;114:154804
44. [IF=3.614] Vinay Naithani et al."Preparation of open tubular capillary column covalently coated with polystyrene sulfonate with 4,4′-Azobis(4-cyanopentanoyl chloride) as polymerization initiator for electrochromatographic separation of alkaloids, sulfonamides, and p
43. [IF=0] Xiaoming Yin et al."Assessment of alkaloids from the stems of 14 Berberis species in China."Separation Science Plus.2022 Dec;:202200114
42. [IF=7.419] Yanlu Liu et al."Coptisine protects against hyperuricemic nephropathy through alleviating inflammation, oxidative stress and mitochondrial apoptosis via PI3K/Akt signaling pathway."BIOMEDICINE & PHARMACOTHERAPY.2022 Dec;156:113941
41. [IF=3.024] Xuan Yu et al."An innovative extraction strategy for herbal medicine by adopting p-sulphonatocalix[6]/[8]arenes."PHYTOCHEMICAL ANALYSIS
40. [IF=6.656] Ye Yang et al."Coptis chinensis polysaccharides dynamically influence the paracellular absorption pathway in the small intestine by modulating the intestinal mucosal immunity microenvironment."PHYTOMEDICINE.2022 Sep;104:154322
39. [IF=1.345] Ya-Li Zhang et al."Coptisine suppresses proliferation and inhibits metastasis in human pancreatic cancer PANC-1 cells."J Asian Nat Prod Res. 2020;22(5):452-463
38. [IF=3.004] Kai Zhang et al."Untargeted metabolomics reveals the synergistic mechanisms of Yuanhu Zhitong oral liquid in the treatment of primary dysmenorrhea."J Chromatogr B. 2021 Feb;1165:122523
37. [IF=3.463] Xiao-Meng Liu et al."Comparative transcriptome analysis provides novel insights into the molecular mechanism of berberine biosynthesis in Coptis chinensis."Sci Hortic-Amsterdam. 2022 Jan;291:110585
36. [IF=3.935] Meng Chen et al."Comprehensive analysis of Huanglian Jiedu decoction: Revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate."J Pharmaceut Biomed. 2021 Feb;195:113820
35. [IF=3.935] Yang Song et al."Pharmacokinetics, tissue distribution and plasma protein binding rate of palmatine following intragastric and intravenous administration in rats using liquid chromatography tandem mass spectrometry."J Pharmaceut Biomed. 2021 Sep;203:11422
34. [IF=3.963] Zhong-min Zhao et al."Anti-phytopathogenic activity and the possible mechanisms of action of isoquinoline alkaloid sanguinarine."Pestic Biochem Phys. 2019 Sep;159:51
33. [IF=4.845] Xiaohong Zhang et al."Laboratory bioassay, greenhouse experiment and 3D-QSAR studies on berberine analogues: a search for new herbicides based on natural products."Pest Manag Sci. 2021 Apr;77(4):2054-2067
32. [IF=5.81] Zhao Jing et al."Intra-Herb Interactions: Primary Metabolites in Coptidis Rhizoma Extract Improved the Pharmacokinetics of Oral Berberine Hydrochloride in Mice."Front Pharmacol. 2021 Jun;0:1426
31. [IF=6.023] Maiquan Li et al."Discovery of Keap1?Nrf2 small?molecule inhibitors from phytochemicals based on molecular docking."Food Chem Toxicol. 2019 Nov;133:110758
30. [IF=6.4] Jing Zhao et al."Natural Nano-Drug Delivery System in Coptidis Rhizoma Extract with Modified Berberine Hydrochloride Pharmacokinetics."Int J Nanomed. 2021; 16: 6297–6311
29. [IF=1.618] Yang Yanfang et al."Determination of Alkaloid Contents in Various Tissues of Coptis Chinensis Franch. by Reversed Phase-High Performance Liquid Chromatography and Ultraviolet Spectrophotometry."J Chromatogr Sci. 2017 May;55(5):556-563
28. [IF=1.618] Li Jiang-Yan et al."Seasonal Variation of Alkaloid Contents and Anti-Inflammatory Activity of Rhizoma coptidis Based on Fingerprints Combined with Chemometrics Methods."J Chromatogr Sci. 2015 Aug;53(7):1131-1139
27. [IF=2.795] Yue Xiao et al."Berberine activates bitter taste responses of enteroendocrine STC-1 cells."Mol Cell Biochem. 2018 Oct;447(1):21-32
26. [IF=3.197] Bingxin Ma et al."Coptis chinensis inflorescence ameliorates hyperglycaemia in 3T3-L1 preadipocyte and streptozotocin-induced diabetic mice."J Funct Foods. 2016 Mar;21:455
25. [IF=3.396] Liang Jie et al."Expression and functional activity of bitter taste receptors in primary renal tubular epithelial cells and M-1 cells."Mol Cell Biochem. 2017 Apr;428(1):193-202
24. [IF=3.935] Ka-Yan Kwok et al."Quality evaluation of commercial Huang-Lian-Jie-Du-Tang based on simultaneous determination of fourteen major chemical constituents using high performance liquid chromatography."J Pharmaceut Biomed. 2013 Nov;85:239
23. [IF=4.759] Lvhuan Wang et al."Online screening of acetylcholinesterase inhibitors in natural products using monolith-based immobilized capillary enzyme reactors combined with liquid chromatography-mass spectrometry."J Chromatogr A. 2018 Aug;1563:135
22. [IF=6.023] Ling Zhu et al."Coptis chinensis inflorescence extract protection against ultraviolet-B-induced phototoxicity, and HPLC–MS analysis of its chemical composition."Food Chem Toxicol. 2012 Jul;50:2584
21. Chen, Meng, et al. "Comprehensive analysis of Huanglian Jiedu decoction: Revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate." Journal of Pharmaceutical and Biomedical Analysis 195 (2021): 113820.https:##
20. Yue, Xiao, et al. "Berberine activates bitter taste responses of enteroendocrine STC-1 cells." Molecular and cellular biochemistry 447.1 (2018): 21-32.https:##doi.org/10.1007/s11010-018-3290-3
19. Ma, Bingxin, et al. "Coptis chinensis inflorescence ameliorates hyperglycaemia in 3T3-L1 preadipocyte and streptozotocin-induced diabetic mice." Journal of Functional Foods 21 (2016): 455-462.https:##doi.org/10.1016/j.jff.2015.12.021
18. Liang, Jie, et al. "Expression and functional activity of bitter taste receptors in primary renal tubular epithelial cells and M-1 cells." Molecular and cellular biochemistry 428.1-2 (2017): 193-202.https:##doi.org/10.1007/s11010-016-2929-1
17. Yang, Yanfang, et al. "Determination of alkaloid contents in various tissues of Coptis chinensis Franch. by reversed phase-high performance liquid chromatography and ultraviolet spectrophotometry." Journal of chromatographic science 55.5 (2017): 556-563. h
16. Zhu, Ling, et al. "Coptis chinensis inflorescence extract protection against ultraviolet-B-induced phototoxicity, and HPLC–MS analysis of its chemical composition." Food and chemical toxicology 50.7 (2012): 2584-2588.https:##doi.org/10.1016/j.fct.2012.04.0
15. 康念欣,袁炎炎,張瀟,路穎慧,李晴霞,李飛,譚鵬.酒黃連HPLC特征圖譜的建立及聚類分析和主成分分析[J].世界科學(xué)技術(shù)-中醫(yī)藥現(xiàn)代化,2020,22(08):2790-2798.
14. 紀(jì)萬里,周澤華,王婷婷,安叡,梁琨,王新宏.基于UPLC-LTQ-Orbitrap-MS方法分析半夏瀉心湯化學(xué)成分[J].藥物分析雜志,2020,40(10):1736-1750.
13. 王盼,儲全根,軒云,蔡正銀.抵當(dāng)陷胸湯HPLC-MS指紋圖譜研究[J].時珍國醫(yī)國藥,2020,31(12):2937-2940.
12. 李聽弦 李蒙 張志 等. 一測多評法測定不同味連飲片中6個生物堿類成分的含量[J]. 藥物分析雜志 2018 038(007):1132-1138.
11. 張瀟, 張亞麗, 苗祥貞,等. 黃連不同炮制品及組分的抗腫瘤活性與6種生物堿含量相關(guān)性研究[J]. 中華中醫(yī)藥雜志, 2019, v.34(06):350-353.
10. 趙露, 江健梅, 孟琦,等. 白屈菜生育期內(nèi)生物堿含量的變化規(guī)律[J]. 吉林農(nóng)業(yè)大學(xué)學(xué)報, 2017(5):590-595.
9. 米佳, 賀文達(dá), 梁心怡,等. 黃連肉桂藥對指紋圖譜的聚類分析及多指標(biāo)的定量分析[J]. 時珍國醫(yī)國藥, 2019, 30(01):83-86.
8. 皮文霞 朱鑫仙 方婷 等. HPLC同時測定"三熱論"方各純化部位中藥根堿、表小檗堿、黃連堿、巴馬汀和小檗堿的含量[J]. 中國實(shí)驗(yàn)方劑學(xué)雜志 2012 18(14):110-113.
7. 李聽弦, 李蒙, 張志,等. 基于高效液相色譜指紋圖譜及紅外光譜評價黃連及其炮制品質(zhì)量差異[J]. 中南藥學(xué), 2019, 017(004):556-560.
6. 曹一佳 曲玉霞 孫雨 等. UPLC-MS/MS法同時測定砂連和胃膠囊中10種化合物含量[J]. 國際藥學(xué)研究雜志 2020 v.47(01):76-81.
5. 房康, 吳高榮, 王輝,等. 黃連解毒湯自沉淀化學(xué)成分及其抗PC12細(xì)胞損傷研究[J]. 中草藥, 2017(18).
4. 柳鑫,楊艷芳,宋紅萍,張小波,黃璐琦,吳和珍.基于MaxEnt和ArcGIS的黃連生長適宜性區(qū)劃研究[J].中國中藥雜志,2016,41(17):3186-3193.
3. 李文芳 王曉明 潘桂湘 等. LC-MS/MS測定養(yǎng)血清腦顆粒中15個生物堿成分的含量[J]. 遼寧中醫(yī)雜志 2017(10):134-136+229.
2. 尚嬋 李孟璇 李海波 何亮偉 孟兆青 黃文哲 王振中 丁崗 楊中林 蕭偉.LC-MS/MS同時測定痛安注射液中13個成分的含量[J].中國中藥雜志 2017 42(10):1901-1907.
1. 王永占 沈勇 史曉倩 韓玙 楊生超 梁艷麗 謝世清.HPLC法同時測定云黃連中四種生物堿的含量[J].中國藥師 2013 16(07):947-949.
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