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黃芩苷

分析標(biāo)準(zhǔn)品,HPLC≥98%

Baicalin

CAS號(hào)：21967-41-9

分子式：C21H18O11

分子量：446.37

MDL：MFCD00134418

別名：黃芩甙，貝加靈

產(chǎn)品介紹

Baicalin 作為一種類黃酮糖苷，是一種變構(gòu)肉堿棕櫚酰轉(zhuǎn)移酶1 (CPT1)是激活劑。Baicalin 降低 NF-KB表達(dá)。

熔點(diǎn)：202-205℃

沸點(diǎn)：836.6 ℃ at 760 mmHg

比旋光度：-85°(C=1, DMSO)

外觀：淡黃色結(jié)晶粉末

溶解性：DMSO  :  ≥  100  mg/mL  (224.03  mM)

H2O  :  0.1  mg/mL  (0.22  mM;  Need  ultrasonic)

儲(chǔ)存條件：2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(206篇)

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204. [IF=2.5] Jie Wang et al."HPMCAS-solidified supersaturated baicalin self-nanoemulsifying drug delivery systems: development and anti-colitis evaluation."PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY.

203. [IF=5.4] Ni Xu et al."Modulation of Glycolytic Metabolic Reprogramming and the TLR4/NF-κB/NLRP3 Pathway: Comparative Analysis of Anti-inflammatory Activity Between Two Dosage Forms of Pudilan Xiaoyan."JOURNAL OF ETHNOPHARMACOLOGY.2025 Jun;:120204

202. [IF=6.5] Xing Liu et al."A Baicalin Liposome-Based Temperature-Sensitive Hydrogel for Treating Ultraviolet-Induced Skin Damage."International Journal of Nanomedicine.2025 Jun;20:7935-7951

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192. [IF=4.4] Dan Song et al."The mechanism of baicalin in improving pulmonary inflammatory response and injury and regulating intestinal flora in Mycoplasma pneumoniae pneumonia mice."CELLULAR SIGNALLING.2025 Feb;126:111530

191. [IF=4.6] Yiyuan Pan et al."Baicalin promotes β-1,3-glucan exposure in Candida albicans and enhances macrophage response."Frontiers in Cellular and Infection Microbiology.2024 Dec;14:

190. [IF=14.3] Shaoqi Qu et al."A Milk Extracellular Vesicle-Based Nanoplatform Enhances Combination Therapy Against Multidrug-Resistant Bacterial Infections."Advanced Science.2024 Dec;:2406496

189. [IF=4.9] Xin Zuo et al."Functional Characterization of β-Glucuronidase Genes Involved in Baicalein Biosynthesis from Scutellaria baicalensis Based on Transcriptome Analysis."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2025 Jan;26(5):1793

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187. [IF=4.2] Xiaoqi Ban et al."In-depth analysis of surface selective adsorption and interfacial mechanisms in the efficient flotation separation of magnesite and dolomite with the environmentally friendly inhibitor baicalin."ADVANCED POWDER TECHNOLOGY.2025 Jun;36:104

186. [IF=4.7] Zhengyao Yu et al."Exploring the Therapeutic and Gut Microbiota-Modulating Effects of Qingreliangxuefang on IMQ-Induced Psoriasis."Drug Design Development and Therapy.

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183. [IF=3.9] Jin Dai et al."Study on the anti-atherosclerosis mechanisms of Tanyu Tongzhi formula based on network pharmacology, Mendelian randomization, and experimental verification."PHARMACEUTICAL BIOLOGY.

182. [IF=7.7] Zhou Li et al."Carboxymethyl chitosan-modified folate-targeted carbon nanotube-baicalin complexes for cancer progression and metastasis."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2024 Oct;:136896

181. [IF=6.7] Tong Tian et al."Qingfei Yin alleviates Streptococcus pneumoniae pneumonia by promoting complete autophagy to suppress necroptosis."PHYTOMEDICINE.2024 Nov;:156280

180. [IF=3.2] Jiahao Zhang et al."Baicalin-Geniposide glycosides inhibit PM2.5-induced brain damage in rats via the 5-LOX/LTB4 pathway."MOLECULAR IMMUNOLOGY.2025 Jan;177:62

179. [IF=11.4] Yameng Cui et al."Baicalin attenuates the immune escape of oral squamous cell carcinoma by reducing lactate accumulation in tumor microenvironment."Journal of Advanced Research.2025 Jan;:

178. [IF=7.7] Mengjiao Li et al."Study on network cross-linked hydrogel with cationic Bletilla striata polysaccharide/carbopol as a drug delivery system."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2025 Feb;:140778

177. [IF=5.7] Yiqing Cai et al."Baicalin mitigates hyperglycemia-linked intestinal epithelial barrier impairment in part by inhibiting the formation of neutrophil extracellular traps."Frontiers in Immunology.2025 Mar;16:

176. [IF=2.9] Tian Hu et al."Baicalin-Geniposide combination modulates microglia polarization against chronic cerebral ischemia and concomitant kidney injury via the HIF-1α/EPO/NF-κB pathway."JOURNAL OF NEUROIMMUNOLOGY.2025 Jun;403:578601

175. [IF=4.9] Zhongda Cao et al."Baicalin Inhibits FIPV Infection In Vitro by Modulating the PI3K-AKT Pathway and Apoptosis Pathway."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2024 Jan;25(18):9930

174. [IF=7.7] Zhenjiang Zheng et al."Growth inhibition of pancreatic cancer by targeted delivery of gemcitabine via fucoidan-coated pH-sensitive liposomes."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2024 Oct;277:134517

173. [IF=2.7] Siqi Zhu et al."Baicalin attenuated oxidative stress and inflammation in ethylene glycol-induced urolithiasis in adult male SD rats."TISSUE & CELL.2024 Jun;:102453

172. [IF=6.9] You Yi-ping et al."Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages."ACTA PHARMACOLOGICA SINICA.2024 Sep;:1-18

171. [IF=4.8] Yongqiang Wen et al."Uncovering the protective mechanism of baicalin in treatment of fatty liver based on network pharmacology and cell model of NAFLD."INTERNATIONAL IMMUNOPHARMACOLOGY.2024 Nov;141:112954

170. [IF=6.2] Jingzheng Li et al."Baicalin ameliorates heat stress-induced hepatic injury and intestinal microecology dysbiosis in late gestational mice."ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY.2024 Sep;283:116832

169. [IF=7.2] Li Huang et al."Development of cantharidin/baicalin co-delivery system based on mitochondrial targeting strategy for enhanced hepatocellular carcinoma therapy."Applied Materials Today.2024 Oct;40:102374

168. [IF=13] Yujie Fan et al."Coordination-Driven Nanomedicine Mitigates One-Lung Ventilation-Induced Lung Injury via Radicals Scavenging and Cell Pyroptosis Inhibition."Small.2024 Aug;:2401056

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166. [IF=6.7] Xianli Xu et al."Bu-Shen-Ning-Xin decoction ameliorates premature ovarian insufficiency by suppressing oxidative stress through rno_circRNA_012284/rno_miR-760-3p/HBEGF pathway."PHYTOMEDICINE.2024 Jul;:155920

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164. [IF=5.4] Dan Yang et al."Study on the Effect of Pharmaceutical Excipient PEG400 on the Pharmacokinetics of Baicalin in Cells Based on MRP2, MRP3, and BCRP Efflux Transporters."Pharmaceutics".2024 Jun;16(6):731

163. [IF=5.4] Rui Guo et al."Tanreqing injection inhibits influenza virus replication by promoting the fusion of autophagosomes with lysosomes: An integrated pharmacological study."JOURNAL OF ETHNOPHARMACOLOGY".2024 Apr;:118159

162. [IF=7.5] Yanfang Zheng et al."Upregulation of Nrf2 signaling: A key molecular mechanism of Baicalin’s neuroprotective action against diabetes-induced cognitive impairment."BIOMEDICINE & PHARMACOTHERAPY".2024 May;174:116579

161. [IF=5.4] Ruolan Sun et al."Homotherapy-for-heteropathy of Bupleurum Chinense DC.-Scutellaria baicalensis Georgi in treating depression and colorectal cancer: A network pharmacology and animal model approach."JOURNAL OF ETHNOPHARMACOLOGY".2024 Mar;:118038

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159. [IF=4.9] Huang Hefei et al."Tanreqing injection inhibits dengue virus encephalitis by suppressing the activation of NLRP3 inflammasome."Chinese Medicine".2024 Dec;19(1):1-17

158. [IF=5.6] Heng Sun et al."Molecular-Scale Investigations Reveal the Effect of Natural Polyphenols on BAX/Bcl-2 Interactions."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES".2024 Jan;25(5):2474

157. [IF=5.6] Haipeng Feng et al."Baicalin Protects Broilers against Avian Coronavirus Infection via Regulating Respiratory Tract Microbiota and Amino Acid Metabolism."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES".2024 Jan;25(4):2109

156. [IF=7.9] Yanqin Luo et al."Scutellaria baicalensis water decoction ameliorates lower respiratory tract infection by modulating respiratory microbiota."PHYTOMEDICINE".2024 May;:155706

155. [IF=5.2] Zhixia Wang et al."A carrier-free organometallic hydrogel originated from natural baicalin and Zn2+ with antibacterial and antioxidant efficacy."COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS.2023 Dec;679:132585

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153. [IF=0.7] Xianyong Li et al."Baicalin Promotes Apoptosis of Human Medullary Breast Cancer via the ERK/p38 MAPK Pathway."Pharmacognosy Magazine.;():

152. [IF=3] Weiwei Dai et al."Baicalin alleviates oxygen–glucose deprivation/reoxygenation-induced SK-N-SH cell injury via the regulation of miR-556-3p/ACSL4 pathway."Chemical Biology & Drug Design.2024 Jan;103(2):e14455

151. [IF=5] Ren Yanying et al."Quercetin: a promising virulence inhibitor of Pseudomonas aeruginosa LasB in vitro."APPLIED MICROBIOLOGY AND BIOTECHNOLOGY.2024 Dec;108(1):1-20

150. [IF=1.8] Yue Qian et al."Si Miao San relieves hyperuricemia by regulating intestinal flora."BIOMEDICAL CHROMATOGRAPHY.2023 Dec;:e5807

149. [IF=2.9] Qi Ying et al."Sanhuang Xiexin Decoction Ameliorates TNBC By Modulating JAK2-STAT3 and Lipid Metabolism."Chinese Journal of Integrative Medicine.2023 Nov;:1-10

148. [IF=5.4] Liangxin Zhao et al."UPLC-Q-Exactive/MS based analysis explore the correlation between components variations and anti-influenza virus effect of four quantified extracts of Chaihu Guizhi decoction."JOURNAL OF ETHNOPHARMACOLOGY.2023 Oct;:117318

147. [IF=3.3] Li Li et al."Baicalin promotes antiviral IFNs production and alleviates type I IFN-induced neutrophil inflammation."Journal of Natural Medicines.2023 Jul;:1-11

146. [IF=4.3] Bao-Fei Yan et al."Huangqin decoction alleviates lipid metabolism disorders and insulin resistance in nonalcoholic fatty liver disease by triggering Sirt1/NF-κB pathway."WORLD JOURNAL OF GASTROENTEROLOGY.2023 Aug 21; 29(31): 4744–4762

145. [IF=6] Shuai Yan et al."Baicalin Suppresses Colorectal Cancer Cell Proliferation, Potentially via ARRDC4: Bioinformatics and Experimental analysis."Arabian Journal of Chemistry.2023 Jul;:105141

144. [IF=5.2] Guo Huanyu et al."The combined effect of a novel formula of herbal extracts on bacterial infection and immune response in Micropterus salmoides."Frontiers in Microbiology.2023 Jun;14:

143. [IF=5.4] Miaomiao Liu et al."Qingjin Huatan decoction protects mice against influenza a virus pneumonia via the chemokine signaling pathways."JOURNAL OF ETHNOPHARMACOLOGY.2023 Dec;317:116745

142. [IF=7.5] Jingwen Yuan et al."Baicalin enhances the efficacy of 5-Fluorouracil in gastric cancer by promoting ROS-mediated ferroptosis."BIOMEDICINE & PHARMACOTHERAPY.2023 Aug;164:114986

141. [IF=3.976] Su Jianqing et al."Pharmacokinetic Studies of Hyperoside-2-hydroxypropyl-β-cyclodextrin Inclusion Complex and It Ameliorated DSS-Induced Colitis in Mice."BIOSCIENCE REPORTS.2023 May;:

140. [IF=4.221] Xixi Fan et al."Baicalin inhibits the replication of the hepatitis B virus by targeting TRIM25."Journal of Traditional and Complementary Medicine.2023 May;:

139. [IF=6.388] Jialing Sun et al."Baicalin inhibits hepatocellular carcinoma cell growth and metastasis by suppressing ROCK1 signaling."PHYTOTHERAPY RESEARCH.2023 May;:

138. [IF=9.965] Junxiao Zhu et al."Are all poorly soluble drugs dissolved in deep eutectic solvents true solutions?."JOURNAL OF COLLOID AND INTERFACE SCIENCE.2023 Sep;645:813

137. [IF=2.139] Y Zhang et al."Baicalin alleviates silica-induced lung inflammation and fibrosis by inhibiting TLR4/NF-?B pathway in rats."PHYSIOLOGICAL RESEARCH.2023 Apr 30;72(2):221-233

136. [IF=2.742] Li Mengyuan et al."Baicalin can enhance odonto/osteogenic differentiation of inflammatory dental pulp stem cells by inhibiting the NF-κB and β-catenin/Wnt signaling pathways."MOLECULAR BIOLOGY REPORTS.2023 Apr;:1-12

135. [IF=9.429] Su Wenting et al."An intravitreal-injectable hydrogel depot doped borneol-decorated dual-drug-coloaded microemulsions for long-lasting retina delivery and synergistic therapy of wAMD."JOURNAL OF NANOBIOTECHNOLOGY.2023 Dec;21(1):1-19

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133. [IF=4.927] Bingyu Shen et al."Baicalin Relieves LPS-Induced Lung Inflammation via the NF-κB and MAPK Pathways."MOLECULES.2023 Jan;28(4):1873

132. [IF=7.419] Mengli Li et al."Baicalin mitigates hypertension-linked alterations in the intestinal lymphatic vasculature in part through preserving the functional barrier integrity of lymphatic endothelial cells."BIOMEDICINE & PHARMACOTHERAPY.2023 Apr;160:114418

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125. [IF=5.168] Pan Wang et al."Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay."CHEMICO-BIOLOGICAL INTERACTIONS.2022 Nov;367:110199

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123. [IF=6.208] Pan Wang et al."Discovery of Flavonoids as Novel Inhibitors of ATP Citrate Lyase: Structure–Activity Relationship and Inhibition Profiles."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2022 Jan;23(18):10747

122. [IF=2.721] Haipeng  Feng et al."Antiviral activity and underlying mechanisms of Baicalin against avian infectious bronchitis virus in vitro."AVIAN PATHOLOGY

121. [IF=5.988] Qihan Luo et al."Chang qing formula ameliorates colitis-associated colorectal cancer via suppressing IL-17/NF-κB/STAT3 pathway in mice as revealed by network pharmacology study."Frontiers in Pharmacology.2022; 13: 893231

120. [IF=6.212] Fei Huang et al."Discovery of conversion driven by β-glucuronidase from flavone glycoside to aglycone and application in identifying the raw Scutellariae Radix."Arabian Journal of Chemistry.2022 Aug;:104216

119. [IF=3.322] Dongjiu Zhao et al."Baicalin promotes antibacterial defenses by modulating mitochondrial function."BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2022 Sep;621:130

118. [IF=5.195] Mengmeng Song et al."Homeostatic regulation of the aryl hydrocarbon receptor-cytochrome P450 1a axis by Scutellaria baicalensis-Coptis chinensis herb pair and its main constituents."JOURNAL OF ETHNOPHARMACOLOGY.2022 Jul;:115545

117. [IF=8.025] Ying Wang et al."Inhibitory activities of flavonoids from Scutellaria baicalensis Georgi on amyloid aggregation related to type 2 diabetes and the possible structural requirements for polyphenol in inhibiting the nucleation phase of hIAPP aggregation."INT

116. [IF=3.935] Yizhu Wang et al."Effects of Scutellaria baicalensis Georgi. on Intestinal Flora in Rats with Spleen Deficiency and Damp-heat."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2022 May;:114831

115. [IF=5.095] Liu  Fengjie et al."Baicalin-loaded folic acid-modified albumin nanoparticles (FA-BSANPs/BA) induce autophagy in MCF-7 cells via ROS-mediated p38 MAPK and Akt/mTOR pathway."Cancer Nanotechnol. 2022 Dec;13(1):1-21

114. [IF=4.072] He Pang et al."Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and β-catenin signaling pathways."J Bone Oncol. 2022 Apr;33:100415

113. [IF=3.205] Wanli Ji et al."Revealing therapeutic targets and mechanism of baicalin for anti-chronic gastritis using proteomic analysis of the gastric tissue."J Chromatogr B. 2022 Mar;:123214

112. [IF=2.193] Zhang Haibo et al.Systematic Study on a Quantitative Analysis of Multicomponents by Single Marker (QAMS) Method for Simultaneous Determination of Eight Constituents in Pneumonia Mixture by UPLC-MS/MS.J Anal Methods Chem. 2021;2021:8311588

111. [IF=4.36] Jiali Zhou et al.The root extract of Scutellaria baicalensis Georgi promotes β cell function and protects from apoptosis by inducing autophagy.J Ethnopharmacol. 2022 Feb;284:114790

110. [IF=1.625] Hong-Jing Sun et al."Baicalin Alleviates Age-Related Macular Degeneration via miR-223/NLRP3-Regulated Pyroptosis."Pharmacology. 2020;105(1-2):28-38

109. [IF=1.851] Rui  Li et al."Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR?146a."Mol Med Rep. 2019 Dec;20(6):5041-5049

108. [IF=1.913] Zheng XP et al."Kidney-targeted baicalin-lysozyme conjugate ameliorates renal fibrosis in rats with diabetic nephropathy induced by streptozotocin.."Bmc Nephrol. 2020 May;21(1):174-174

107. [IF=2.193] Xue Gen et al."Integrating Study on Qualitative and Quantitative Characterization of the Major Constituents in Shuanghuanglian Injection with UHPLC/Q-Orbitrap-MS and UPLC-PDA."J Anal Methods Chem. 2021;2021:9991363

106. [IF=2.193] Xu Tong et al."A Preferable Approach for the Quality Control of Xiaoer Chiqiao Qingre Granules Based on the Combination of Chromatographic Fingerprints and Chemometrics."J Anal Methods Chem. 2020;2020:6836981

105. [IF=2.877] Wanli Ji et al."Identifying the active compounds and mechanism of action of Banxia Xiexin decoction for treating ethanol-induced chronic gastritis using network pharmacology combined with UPLC–LTQ–Orbitrap MS."Comput Biol Chem. 2021 Aug;93:107535

104. [IF=3] Qu  Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950

103. [IF=3.361] Mengmeng Yuan et al."The interaction of dietary flavonoids with xanthine oxidase in vitro: molecular property-binding affinity relationship aspects."Rsc Adv. 2019 Apr;9(19):10781-10788

102. [IF=3.882] Kunpeng Yin et al."Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine."Langmuir. 2021;37(17):5321–5328

101. [IF=3.935] Zhengchao Ji et al."Global identification and quantitative analysis of representative components of Xin-Nao-Kang Capsule, a traditional Chinese medicinal formula, by UHPLC-Q-TOF-MS and UHPLC-TQ-MS."J Pharmaceut Biomed. 2021 May;198:114002

100. [IF=3.935] Meng Chen et al."Comprehensive analysis of Huanglian Jiedu decoction: Revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate."J Pharmaceut Biomed. 2021 Feb;195:113820

99. [IF=3.935] Chenglong Sun et al."A spatially-resolved approach to visualize the distribution and biosynthesis of flavones in Scutellaria baicalensis Georgi."J Pharmaceut Biomed. 2020 Feb;179:113014

98. [IF=4.162] Leyi Ma et al."Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway."Drug Des Dev Ther. 2021; 15: 3207–3221

97. [IF=4.225] Wu  Dandan et al."Baicalin Protects Against Hypertension-Associated Intestinal Barrier Impairment in Part Through Enhanced Microbial Production of Short-Chain Fatty Acids."Front Pharmacol. 2019 Oct;0:1271

96. [IF=4.545] Xiangyan Wu et al."Qingda granules attenuate hypertensive cardiac remodeling and inflammation in spontaneously hypertensive rats."Biomed Pharmacother. 2020 Sep;129:110367

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